Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis . Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation . Ubiquitinates SMURF2 through ''Lys-48''-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation . Promotes ''Lys-63''-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair . In addition, promotes an atypical ''Lys-29''-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction . Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta-catenin signaling pathway . .

q9buz4

TNF receptor-associated factor 4 (EC 2.3.2.27) (Cysteine-rich domain associated with RING and Traf domains protein 1) (Metastatic lymph node gene 62 protein) (MLN 62) (RING finger protein 83),TRAF4 CART1 MLN62 RNF83,CART1,MLN62,RING finger protein 83,TRAF4,MLN 62,Cysteine-rich domain associated with RING and Traf domains protein 1,RNF83,Metastatic lymph node gene 62 protein,TNF receptor-associated factor 4

Human, Mouse, Rat

WB,IHC,ELISA

WB 1:500-1:2000
IHC 1:50-1:300
ELISA 1:5000-1:20000

54kD

Rabbit

Recombinant Human TRAF4 (Gln193-Asp444).

Polyclonal

IgG

Purified by antigen affinity column.

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.