E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of ''Lys-63''-linked-polyubiquitin chains conjugated to proteins, such as ECSIT, IKBKG, IRAK1, AKT1 and AKT2 . Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation . Leads to the activation of NF-kappa-B and JUN . Seems to also play a role in dendritic cells (DCs) maturation and/or activation (By similarity). Represses c-Myb-mediated transactivation, in B-lymphocytes . Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor . Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation (By similarity). Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (By similarity). Acts as a regulator of the JNK and NF-kappa-B signaling pathways by initiating assembly of heterotypic ''Lys-63''-/''Lys-48''-linked branched ubiquitin chains that are then recognized by TAB2: TRAF6 catalyzes initial ''Lys-63''-linked-polyubiquitin chains that are then branched via ''Lys-48''-linked polyubiquitin by HUWE1 . ''Lys-63''-/''Lys-48''-linked branched ubiquitin chains protect ''Lys-63''-linkages from CYLD deubiquitination . Participates also in the TCR signaling by ubiquitinating LAT . .

q9y4k3

TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6),TRAF6 RNF85,RING finger protein 85,RING-type E3 ubiquitin transferase TRAF6,Interleukin-1 signal transducer,TRAF6,TNF receptor-associated factor 6,E3 ubiquitin-protein ligase TRAF6,RNF85

Human, Mouse, Rat

WB,IHC,ELISA

WB 1:500-1:2000
IHC 1:50-1:300
ELISA 1:5000-1:20000

60kD

Rabbit

Recombinant Human TRAF6 (Gln348-Asp504).

Polyclonal

IgG

Purified by antigen affinity column.

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.