Voltage-gated sodium channels (Nav) gating-modifier. Acts both as alpha- and beta-toxin, since it affects not only activation but also inactivation of Nav channels (Probable) . Binds to Nav domain DII and impairs the four Nav channel voltage sensors movements . Depending on Nav channel subtypes tested, can also bind Nav domains DIII (low affinity) and DIV (very low affinity) . Acts on almost all the Nav channels tested (mammalian Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN4A, Nav1.5/SCN5A, Nav1.6/SCN8A, Nav1.9/SCN11A, and insect DmNav1) . Is highly active against both mammals and insects . Irreversibly modulates DmNav channels . Other Ts1 activities have been studied, such as immunomodulation, antimicrobial activity or exocrine secretion (Probable). This toxin exhibits an antifungal activity against filamentous fungi . In vitro, it has an important immunomodulatory effect on macrophages by stimulating the release of pro-inflammatory cytokines . It also shows an activity in exocrine secretion in pancreas, stomach and adrenal gland . .

p15226

Beta-mammal/insect toxin Ts1 (Beta-like toxin Ts1) (PT-Mice-Ins-beta NaTx6.1) (Tityustoxin VII) (Toxin VII) (Ts VII) (Ts7) (TsTX-VII) (Toxin II-11) (Toxin III-10) (Toxin T2-IV) (Toxin gamma) (T-gamma) (TiTx gamma) (Toxin-g) (TsTX-I),Beta-mammal/insect toxin Ts1, Beta-like toxin Ts1, PT-Mice-Ins-beta NaTx6.1, Tityustoxin VII, Toxin VII, Ts VII, Ts7, TsTX-VII, Toxin II-11, Toxin III-10, Toxin T2-IV, Toxin gamma, T-gamma, TiTx gamma, Toxin-g, TsTX-I

Tityus serrulatus (Brazilian scorpion)

ELISA,Neutralization

ELISA 1:5000-1:20000
Neutralization,The optimal dilutions should be determined by the end user.

10kD

Human

Monoclonal

Iv381

IgG1, kappa

Protein A/G purified from cell culture supernatant.

>95% as determined by SDS-PAGE.

0.01M PBS, pH 7.4.

1 mg/ml

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.

For research use only. Not suitable for clinical or therapeutic use.