Multifunctional protein essential for viral DNA replication, which cooperatively interacts with the viral DNA origin of replication and transactivates several promoters including the viral p6 promoter . Binds the origin of replication and performs an endonucleolytic nick within a conserved sequence in the viral genome, thereby initiating the rolling circle replication (RCR) . Participates in the transcriptional regulation the viral p6 promoter that regulates all viral transcripts and the cellular CDN1A or IL6 promoters . Transactivates several host promoters some of which induce the S cell cycle phase for the production of host replicative proteins . Up-regulates the expression of host E2F4 and E2F5 and interacts with both these factors thereby inhibiting the host cell cycle G2/M transition . This arrest promotes apoptosis for viral release . .

q9pzt1, p07298

Initiator protein NS1 (NS1) (EC 3.1.21.-) (EC 3.6.4.12) (NCVP1) (Non-capsid protein NS-1) (Non-structural protein 1) (Non-structural protein NS1),NS1,Initiator protein NS1, NS1, 3.1.21.-, 3.6.4.12, NCVP1, Non-capsid protein NS-1, Non-structural protein 1, Non-structural protein NS1, NS1

Human parvovirus B19 (strain HV) (HPV B19), Human parvovirus B19 (isolate AU) (HPV B19)

ELISA,Neutralization

ELISA 1:5000-1:20000
Neutralization,The optimal dilutions should be determined by the end user.

75kD

Human

Monoclonal

Iv253

IgG1, kappa

Protein A/G purified from cell culture supernatant.

>95% as determined by SDS-PAGE.

0.01M PBS, pH 7.4.

1 mg/ml

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.

For research use only. Not suitable for clinical or therapeutic use.