Component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system . C1S is activated following association of the C1 complex with immunoglobulins (IgG or IgM) complexed with antigens to form antigen-antibody complexes on the surface of pathogens . C1S is cleaved and activated by C1R to generate C1s subcomponent heavy and light chains . C1s subcomponent light chain then cleaves and activates C2 and C4, the next components of the classical complement pathway . .; [Complement C1s subcomponent light chain]: Serine protease component of the complement C1 complex, which catalyzes cleavage and activation of C2 and C4, the next components of the classical complement pathway . Also able to cleave C1 inhibitor (SERPING1) in vitro; additional evidence is however required to confirm this result in vivo . Also cleaves IGFBP5 and thereby inhibits the trophic effects of IGF1 . .

p09871

Complement C1s subcomponent (EC 3.4.21.42) (C1 esterase) (Complement component 1 subcomponent s) [Cleaved into: Complement C1s subcomponent heavy chain (Complement C1s subcomponent chain A); Complement C1s subcomponent light chain (Complement C1s subcomponent chain B)],C1S,C1 esterase, Complement C1s subcomponent, C1S, Complement component 1 subcomponent s

Human

WB,FC,ELISA,Neutralization

WB 1:500-1:2000
FC 1:50-1:200
ELISA 1:5000-1:20000
Neutralization,The optimal dilutions should be determined by the end user.

77kD

Mouse

Monoclonal

TN249

IgG2a, kappa

Protein A/G purified from cell culture supernatant.

>95% as determined by SDS-PAGE.

0.01M PBS, pH 7.4.

1 mg/ml

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4℃ short term (1-2 weeks). Store at -20℃ 12 months.

For research use only. Not suitable for clinical or therapeutic use.