Testis-specific chromatin protein that specifically binds histone H4 acetylated at ''Lys-5'' and ''Lys-8'' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis . Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time . In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA . Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated at ''Lys-8'' (H4K8ac), while it is not able to bind H4 butyrylated at ''Lys-5'' (H4K5ac) (By similarity). Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3''-UTR truncation of specific mRNAs in post-meiotic spermatids (By similarity). Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin.

Q58F21

676

Bromodomain testis-specific protein, Cancer/testis antigen 9, CT9, RING3-like protein, BRDT

Human,Monkey

WB

WB 1:2000

108 kD

Rabbit

Polyclonal

Rabbit IgG

This antibody is purified by peptide affinity purification.

PBS (pH7.4) with 0.09% (W/V) sodium azide.

Store at -20°C. Stable for 12 months from date of receipt.Do not aliquot the antibody.Avoid freeze / thaw cycle.