Subunit of STT3A-containing oligosaccharyl transferase (OST-A) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation . N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER) . Within the OST-A complex, acts as an adapter that anchors the OST-A complex to the Sec61 complex . May be involved in N-glycosylation of APP (amyloid-beta precursor protein) . Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1 .

Q8N6L1

200185

Keratinocyte-associated protein 2, KCP-2, KRTCAP2, KCP2

Human,Mouse,Rat

WB,IHC

WB 1:1000
IHC 1:100-500

15 kD

Rabbit

Polyclonal

Rabbit IgG

This antibody is purified by peptide affinity purification.

PBS (pH7.4) with 0.09% (W/V) sodium azide.

Store at -20°C. Stable for 12 months from date of receipt.Do not aliquot the antibody.Avoid freeze / thaw cycle.