[Isoform 1]: Apoptosis regulator that functions through different apoptotic signaling pathways . Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner . In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release . In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner . Plays a role in granulosa cell apoptosis by CASP3 activation . Plays a roles as anti-apoptotic protein during neuronal apoptotic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation (By similarity). In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression . May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1 . ; [Isoform 2]: Pro-apoptotic molecule exerting its function through the mitochondrial pathway.

Q9UMX3

666

Bcl-2-related ovarian killer protein, hBOK, Bcl-2-like protein 9, Bcl2-L-9, BOK, BCL2L9

Human,Mouse,Rat,Bovine,Chicken,Xenopus,Pig,Monkey,Zebrafish,Rabbit,Hamster,Drosophila,C.Elegans,Yeast,SARS,Vaccinia Virus,Neisseria Gonorrhoeae

WB,IHC

WB 1:1000
IHC 1:100-500

24 kD

Rabbit

Polyclonal

Rabbit IgG

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

PBS (pH7.4) with 0.09% (W/V) sodium azide.

Store at -20°C. Stable for 12 months from date of receipt.Do not aliquot the antibody.Avoid freeze / thaw cycle.