Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses . In response to non-canonical NF-kappa-B stimuli, deubiquitinates ''Lys-48''-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B (By similarity). Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B . Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR . Has deubiquitinating activity toward ''Lys-11'', ''Lys-48'' and ''Lys-63''-linked polyubiquitin chains . Has a much higher catalytic rate with ''Lys-11''-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure . Hydrolyzes both linear and branched forms of polyubiquitin . Acts as a regulator of mTORC1 and mTORC2 assembly by mediating ''Lys-63''-linked deubiquitination of MLST8, thereby promoting assembly of the mTORC2 complex, while inibiting formation of the mTORC1 complex .

Q6GQQ9

56957

OTU domain-containing protein 7B, Cellular zinc finger anti-NF-kappa-B protein, Zinc finger A20 domain-containing protein 1, Zinc finger protein Cezanne, OTUD7B, ZA20D1

Human,Mouse

WB,IHC

WB 1:1000
IHC 1:100-500

93 kD

Rabbit

Polyclonal

Rabbit IgG

This antibody is purified by peptide affinity purification.

PBS (pH7.4) with 0.09% (W/V) sodium azide.

Store at -20°C. Stable for 12 months from date of receipt.Do not aliquot the antibody.Avoid freeze / thaw cycle.