NAD-dependent protein deacetylase . Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues . Known targets include ACSS1, IDH, GDH, PDHA1, SOD2, LCAD, SDHA, MRPL12 and the ATP synthase subunit ATP5PO . Contributes to the regulation of the cellular energy metabolism . Important for regulating tissue-specific ATP levels . In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription . Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation . Regulates hepatic lipogenesis . Uses NAD(+) substrate imported by SLC25A47, triggering downstream activation of PRKAA1/AMPK-alpha signaling cascade that ultimately downregulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance . In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating delactylation of proteins, such as CCNE2 and ''Lys-16'' of histone H4 (H4K16la) (By similarity).

Q8R104

64384

NAD-dependent protein deacetylase sirtuin-3, 351-, Regulatory protein SIR2 homolog 3, SIR2-like protein 3, mSIR2L3, Sirt3, Sir2l3

Human,Mouse

WB,IHC

WB 1:64000
IHC 1:50-1:200

37 kD

Rabbit

Polyclonal

Rabbit IgG

This antibody is purified by peptide affinity purification.

PBS (pH7.4) with 0.09% (W/V) sodium azide.

Store at -20°C. Stable for 12 months from date of receipt.Do not aliquot the antibody.Avoid freeze / thaw cycle.