Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins . Forms homotetramers which encircle a large channel traversing the endoplasmic reticulum (ER) membrane . This allows the retrotranslocation of misfolded proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome . The channel has a lateral gate within the membrane which provides direct access to membrane proteins with no need to reenter the ER lumen first . May mediate the interaction between VCP and the misfolded protein . Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation . By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway . ; (Microbial infection) In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.

Q9BUN8

79139

Derlin-1, Degradation in endoplasmic reticulum protein 1, DERtrin-1, Der1-like protein 1, DERL1, DER1

Human,Mouse,Bovine

WB,IHC,FC

WB 1:1000
IHC 1:100-500
FC 1:10-50

29 kD

Rabbit

Polyclonal

Rabbit IgG

This antibody is purified by peptide affinity purification.

PBS (pH7.4) with 0.09% (W/V) sodium azide.

Store at -20°C. Stable for 12 months from date of receipt.Do not aliquot the antibody.Avoid freeze / thaw cycle.