Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS) . Initiates HS synthesis by transferring the first N-acetyl-alpha-D-glucosamine (alpha-GlcNAc) residue (GlcNAcT-I activity) to the tetrasaccharide linker (GlcA-Gal-Gal-Xyl-)Ser core linker . May also transfer alpha-GlcNAc residues during HS elongation (GlcNAcT-II activity) . Lacks glucuronyl transferase II (GlcAT-II) activity . Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs) . Through the synthesis of HS, regulates postnatal pancreatic islet maturation and insulin secretion (By similarity). ; Receptor for REG3A, REG3B and REG3G, induces the activation of downstream signaling pathways such as PI3K-AKT or RAS-RAF-MEK-ERK signaling pathway . Required for the function of REG3A in regulating keratinocyte proliferation and differentiation . Required for the inhibition of skin inflammation mediated by REG3A through the activation of PI3K-AKT-STAT3 pathway . Required for the function of REG3A and REG3G in glucose tolerance in pancreas . Expressed in microglia, is activated by nociceptor-derived REG3G in response to endotoxins, leading to the inhibition of kynurenine pathway to prevent endotoxic death (By similarity).

O43909

2137

Exostosin-like 3, EXT-related protein 1, Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, Hereditary multiple exostoses gene isolog, Multiple exostosis-like protein 3, Putative tumor suppressor protein EXTL3, EXTL3, EXTL1L, EXTR1, KIAA0519

Human

WB,IHC,FC

WB 1:1000
IHC 1:100-500
FC 1:10-50

105 kD

Rabbit

Polyclonal

Rabbit IgG

This antibody is purified by peptide affinity purification.

PBS (pH7.4) with 0.09% (W/V) sodium azide.

Store at -20°C. Stable for 12 months from date of receipt.Do not aliquot the antibody.Avoid freeze / thaw cycle.