Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs . Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5''-phosphorylated mRNA fragment and 7m-GDP . Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay . Plays a role in replication-dependent histone mRNA degradation . Has higher activity towards mRNAs that lack a poly(A) tail . Has no activity towards a cap structure lacking an RNA moiety . The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2''-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping . Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts .
Q8IU60
167227
m7GpppN-mRNA hydrolase, Nucleoside diphosphate-linked moiety X motif 20, Nudix motif 20, mRNA-decapping enzyme 2, hDpc, DCP2, NUDT20
Human,Mouse
WB,IHC,FC
WB 1:1000IHC 1:100-500FC 1:10-50
49 kD
Rabbit
Polyclonal
Rabbit IgG
This antibody is purified by peptide affinity purification.
PBS (pH7.4) with 0.09% (W/V) sodium azide.
Store at -20°C. Stable for 12 months from date of receipt.Do not aliquot the antibody.Avoid freeze / thaw cycle.
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