Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, SCF(FBXO3), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome . In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented . PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation . The SCF(FBXO3) also acts as a regulator of inflammation by mediating ubiquitination and degradation of FBXL2 in response to lipopolysaccharide (LPS) . The SCF(FBXO3) complex specifically recognizes FBXL2 phosphorylated at ''Thr-404'' and promotes its ubiquitination . ; (Microbial infection) Associates with the Rift valley fever virus NSs to form a remodeled E3 ligase that triggers efficient proteasomal degradation of targeted proteins. The filamentous E3 ligase targets the TFIIH complex leading to robust inhibition of antiviral immunity and enhances viral pathogenesis.

Q9UK99

26273

F-box only protein 3, FBXO3, FBX3

Human,Mouse,Rat,Bovine

WB,FC

WB 1:1000
FC 1:10-50

55 kD

Rabbit

Polyclonal

Rabbit IgG

This antibody is purified by peptide affinity purification.

PBS (pH7.4) with 0.09% (W/V) sodium azide.

Store at -20°C. Stable for 12 months from date of receipt.Do not aliquot the antibody.Avoid freeze / thaw cycle.