Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and memory . Upon extracellular pH drop this channel elicits transient, fast activating, and completely desensitizing inward currents . Displays high selectivity for sodium ions but can also permit the permeation of other cations . Regulates more or less directly intracellular calcium concentration and CaMKII phosphorylation, and thereby the density of dendritic spines. Modulates neuronal activity in the circuits underlying innate fear (By similarity). ; [Isoform Asic1a]: Has high selectivity for sodium ions, but can also be permeable to other cations including calcium, lithium and potassium. ; [Isoform Asic1b]: Produces acid activated currents with a reduced amplitude and inactivates faster . Has high selectivity for sodium ions but also supports a calcium-mediated current which is sustained and maintained as long as acidic conditions are present . Also potentially permeable to lithium and potassium . ; [Isoform 1]: Has no measurable proton-gated sodium channel activity in vitro.

P78348

41

Acid-sensing ion channel 1, ASIC1, Amiloride-sensitive cation channel 2, neuronal, Brain sodium channel 2, BNaC2, ASIC1, ACCN2, BNAC2

Human,Mouse,Rat,Chicken

WB,IHC,FC

WB 1:1000
IHC 1:100-500
FC 1:10-50

60 kD

Rabbit

Polyclonal

Rabbit IgG

This antibody is purified by peptide affinity purification.

PBS (pH7.4) with 0.09% (W/V) sodium azide.

Store at -20°C. Stable for 12 months from date of receipt.Do not aliquot the antibody.Avoid freeze / thaw cycle.