Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ''Lys-119'', rendering chromatin heritably changed in its expressibility . Component of a PRC1-like complex that mediates monoubiquitination of histone H2A ''Lys-119'' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females . May stimulate ubiquitination of histone H2A ''Lys-119'' by recruiting the complex to target sites . Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (By similarity). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis . May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (By similarity). May bind to DNA . May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 .

Q8CCI5

56353

RING1 and YY1-binding protein, Death effector domain-associated factor, DED-associated factor, Rybp, Dedaf

Human,Mouse

WB

WB 1:2000

25 kD

Rabbit

polyclonal

Rabbit IgG

This antibody is purified by peptide affinity purification.

PBS (pH7.4) with 0.09% (W/V) sodium azide.

Store at -20°C. Stable for 12 months from date of receipt.Do not aliquot the antibody.Avoid freeze / thaw cycle.