Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine . Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4 . Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion . Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation . Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change . Stimulates plasminogen activation . Plays a role in male fertility . Plays a protective role in early postimplantation embryonic development (By similarity). Also responsible for the deamination of cordycepin (3''-deoxyadenosine), a fungal natural product that shows antitumor, antibacterial, antifungal, antivirus, and immune regulation properties .

P00813

100

ADA; ADA1; Adenosine deaminase; Adenosine aminohydrolase

Human,Mouse

WB,FC

WB 1:1000
FC 1:100

41 kD

Rabbit

Polyclonal

Rabbit IgG

This antibody is purified by peptide affinity purification.

PBS (pH7.4) with 0.09% (W/V) sodium azide.

Store at -20°C. Stable for 12 months from date of receipt.Do not aliquot the antibody.Avoid freeze / thaw cycle.