This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],

Transcription factor E3,TFE3;BHLHE33;Transcription factor E3;Class E basic helix-loop-helix protein 33;bHLHe33,TFE3

P19532,Q64092

Human,Mouse,Rat

WB,IHC,IF,ICC,ELISA

WB 1:1000-1:5000
IHC 1:100-1:500
IF 1:200-1:1000
ICC 1:200-1:1000
ELISA 1:5000-1:20000

72-89kDa

Cytoplasm, cytosol . Nucleus . When nutrients are present, phosphorylation by MTOR prevents nuclear translocation and activity (PubMed:22692423, PubMed:30733432). Conversely, inhibition of mTORC1, starvation and lysosomal disruption, promotes dephosphorylation and translocation to the nucleus (PubMed:22692423, PubMed:30733432). .

Rabbit

Monoclonal

IgG,Kappa

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

-20°C/1 year(Do not lower than -25°C)