catalytic activity:NADH + ubiquinone = NAD(+) + ubiquinol.,disease:Defects in MT-ND1 are a cause of Leber hereditary optic neuropathy (LHON) [MIM:535000]. LHON is a maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes.,disease:Defects in MT-ND1 are a cause of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome (MELAS) [MIM:540000]. MELAS is a genetically heterogenious disorder, characterized by episodic vomiting, seizures, and recurrent cerebral insults resembling strokes and causing hemiparesis, hemianopsia, or cortical blindness.,disease:Defects in MT-ND1 may be associated with mitochondrial susceptibility to Alzheimer disease (AD) [MIM:502500].,disease:Defects in MT-ND1 may be associated with non-insulin-dependent diabetes mellitus (NIDDM).,function:Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.,similarity:Belongs to the complex I subunit 1 family.,

NADH-ubiquinone oxidoreductase chain 1,MT-ND1;MTND1;NADH1;ND1;NADH-ubiquinone oxidoreductase chain 1;NADH dehydrogenase subunit 1,MT-ND1

P03886,P03888

Human,Mouse,Rat

WB,IHC,IF,ICC,ELISA

WB 1:1000-1:5000
IHC 1:100-1:200
IF 1:200-1:1000
ICC 1:200-1:1000
ELISA 1:5000-1:20000

43kDa

Mitochondrion inner membrane ; Multi-pass membrane protein .

Rabbit

Monoclonal

IgG,Kappa

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

-20°C/1 year(Do not lower than -25°C)