The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012],

Tumor necrosis factor receptor superfamily member 11A (Osteoclast differentiation factor receptor) (ODFR) (Receptor activator of NF-KB) (CD antigen CD265),Tumor necrosis factor receptor superfamily member 11A;Osteoclast differentiation factor receptor;ODFR;Receptor activator of NF-KB;CD antigen CD265;RANK,TNFRSF11A

Q9Y6Q6,O35305

Human,Mouse,Rat

WB,IHC,IF,ICC,ELISA

WB 1:10000-1:50000
IHC 1:200-1:1000
IF 1:200-1:1000
ICC 1:200-1:1000
ELISA 1:5000-1:20000

70kDa

[Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform RANK-e5a]: Cell membrane ; Single-pass type I membrane protein .

Rabbit

Monoclonal

IgG,Kappa

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

-20°C/1 year(Do not lower than -25°C)