13916964679
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling . Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation . After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members . PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK . BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways . Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway . The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense . Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells . Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation . BTK also plays a critical role in transcription regulation . Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes . BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B . Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 . Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR . GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression . ARID3A and NFAT are other transcriptional target of BTK . BTK is required for the formation of functional ARID3A DNA-binding complexes . There is however no evidence that BTK itself binds directly to DNA . BTK has a dual role in the regulation of apoptosis . .
Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) BTK AGMX1 ATK BPK
Human,Mouse,Rat
WB,IHC
WB 1:500-1:2000IHC 1:50-1:200
76kDa
BTK AGMX1 ATK BPK
q06187
Rabbit
Polyclonal
Rabbit IgG
Adaptive immunity #B-cell activation #Innate immunity
PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Store at -20 °C. Stable for 12 months from date of receipt.
艾比玛特医药科技（上海）有限公司
上海市徐汇区桂平路333号聚科生物园区1号楼1-3层
邮箱：market@ab-mart.com
应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
技术支持：15618194176（微信同号）
华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
华北经销商负责（北京，天津，河北）：
徐经理：手机15618191473（微信同号）
南方经销商负责：
陆经理：手机13122837132（微信同号）
北方及西南经销商负责：
张经理：手机13122150513（微信同号）
微信客服
邮箱：market@ab-mart.com
应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
技术支持：15618194176（微信同号）
华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
华北经销商负责（北京，天津，河北）：
徐经理：手机15618191473（微信同号）
南方经销商负责：
陆经理：手机13122837132（微信同号）
北方及西南经销商负责：
张经理：手机13122150513（微信同号）
微信客服
沪ICP备17056956号-2 艾比玛特医药科技（上海）有限公司
