Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway.
WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1) (Atg18 protein homolog) (WD40 repeat protein interacting with phosphoinositides of 49 kDa) (WIPI 49 kDa) WIPI1 WIPI49
Human, Mouse
WB,IHC,ELISA
WB 1:500-1:2000IHC 1:20-1:200ELISA 1:5000-1:20000
48.673 kDa ;
WIPI1 WIPI49
q5mnz9
Recombinant Human WD repeat domain phosphoinositide-interacting protein 1 protein (187-446AA)
Rabbit
Polyclonal
IgG
Cancer; Metabolism; Signal transduction
>95%, Antigen Affinity Purified
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Store at -20°C. Do not aliquot the antibody
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