13916964679
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at \\\\\\'Arg-54\\\\\\' (to form H1R54ci), histone H3 at \\\\\\'Arg-2\\\\\\', \\\\\\'Arg-8\\\\\\', \\\\\\'Arg-17\\\\\\' and/or \\\\\\'Arg-26\\\\\\' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at \\\\\\'Arg-3\\\\\\' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of \\\\\\'Arg-54\\\\\\' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at \\\\\\'Arg-2142\\\\\\', which favors its interaction with NCOA2/GRIP1.
Protein-arginine deiminase type-4 (EC 3.5.3.15) (HL-60 PAD) (Peptidylarginine deiminase IV) (Protein-arginine deiminase type IV) PADI4 PAD4 PADI5 PDI5
Human
WB,IHC,ELISA
WB 1:1000-1:2000IHC 1:20-1:200ELISA 1:5000-1:20000
74.079 kDa ;
PADI4 PAD4 PADI5 PDI5
q9um07
Recombinant Human Protein-arginine deiminase type-4 protein (1-250AA)
Rabbit
Polyclonal
IgG
Epigenetics and Nuclear Signaling; Cancer; Metabolism; Signal transduction
>95%, Antigen Affinity Purified
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Store at -20°C. Do not aliquot the antibody
艾比玛特医药科技（上海）有限公司
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订购专线：4006-123-828
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技术支持：15618194176（微信同号）
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南方经销商负责：
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北方及西南经销商负责：
张经理：手机13122150513（微信同号）
微信客服
邮箱：market@ab-mart.com
应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
技术支持：15618194176（微信同号）
华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
华北经销商负责（北京，天津，河北）：
徐经理：手机15618191473（微信同号）
南方经销商负责：
陆经理：手机13122837132（微信同号）
北方及西南经销商负责：
张经理：手机13122150513（微信同号）
微信客服
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