Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage . In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form . Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes . Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival . Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form . Binds to inverted 5'-NGAAN-3' pentamer DNA sequences . Binds to chromatin at heat shock gene promoters . Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 . Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells . Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner . Plays a role in nuclear export of stress-induced HSP70 mRNA . Plays a role in the regulation of mitotic progression . Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner . Involved in stress-induced cancer cell proliferation in a IER5-dependent manner . .; (Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300. .

Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1) HSF1 HSTF1

Mouse;Human

WB,IHC

WB 1:1000-1:2000
IHC 1:50-1:200

57.260kD;

HSF1 HSTF1

q00613

https://www.uniprot.org/uniprotkb/q00613

RKRA43542-Recombinant Heat Shock Transcription Factor 1 (HSF1) Val15~Pro288

Rabbit

Polyclonal

Rabbit IgG

Signal transduction;Tumor immunity;Developmental science;

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Liquid

0.58mg/ml

0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.