PK70776

货号 规格 价格(¥)
PK70776S 50μl
PK70776M 100μl

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Note:  Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.

注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。

抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。

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   植物BPP法变性蛋白提取

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经典一抗-MyD88 Antibody

Datasheet

Background

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response . Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response . Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway . Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes . Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses, induces IL1B release through NLRP3 inflammasome activation (By similarity). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine . Mediates leukocyte recruitment at the inflammatory site . .; [Isoform 2]: Defective in its ability to induce IRAK phosphorylation and NF-kappa-B activation and can function as a negative regulator of activation by IL-1 or lipopolysaccharide (LPS). .

Alternative Name

Myeloid differentiation primary response protein MyD88 Myd88

Reactivity

Rat;Mouse

Predicted Reactivity

Application

WB,IHC,IF,ICC

Application Image

Recommended Dilution

WB 1:300-1:1000
IHC 1:50-1:200
IF 1:100-1:400
ICC 1:100-1:400

Mol Weight

33.753kD;

Gene Symbol

Myd88

Uniprot

p22366

Uniprot link

Immunogen

RKRB70781-Recombinant Myeloid Differentiation Factor 88 (MyD88) Arg32~Pro265

Immunogen Range

Source

Rabbit

Clonality

Polyclonal

Isotype

Rabbit IgG

Specificity

Subcellular location

Research Area

Signal transduction;CD Adhesion molecule;Tumor immunity;Pulmonology;

Positive control

Conjugation

Modification

Purification

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Formulation

Liquid

Concentration

500μg/mL

Buffer

0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

产品介绍

Clone

Target

波长

Storage

Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.

注意事项

Companion Products

Important

Comments

RRID

客户评价

艾比玛特医药科技(上海)有限公司
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技术支持:15618194176(微信同号)

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南方经销商负责:

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北方及西南经销商负责:

张经理:手机13122150513(微信同号)

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      微信客服

邮箱:market@ab-mart.com

应聘职位:hr@ab-mart.com

订购专线:4006-123-828

销售电话:13916964679(微信同号)

技术支持:15618194176(微信同号)

华南经销商负责(广东,广西,福建,海南):
程经理:手机18616261485(微信同号)
华北经销商负责(北京,天津,河北):
徐经理:手机15618191473(微信同号)
南方经销商负责:

陆经理:手机13122837132(微信同号)
北方及西南经销商负责:

张经理:手机13122150513(微信同号)

46c73bc4c7a4d51a3ce472aedb80205b_compress.jpg

      微信客服

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