Antimicrobial protein that is an integral component of the innate immune system . Binds to bacterial lipopolysaccharides (LPS) . Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 . Postsecretory processing generates multiple cathelicidin antimicrobial peptides with various lengths which act as a topical antimicrobial defense in sweat on skin . The unprocessed precursor form, cathelicidin antimicrobial peptide, inhibits the growth of Gram-negative E.coli and E.aerogenes with efficiencies comparable to that of the mature peptide LL-37 (in vitro) . .; [Antibacterial peptide LL-37]: Antimicrobial peptide that is an integral component of the innate immune system . Binds to bacterial lipopolysaccharides (LPS) . Causes membrane permeabilization by forming transmembrane pores (in vitro) . Causes lysis of E.coli . Exhibits antimicrobial activity against Gram-negative bacteria such as P.aeruginosa, S.typhimurium, E.aerogenes, E.coli and P.syringae, Gram-positive bacteria such as L.monocytogenes, S.epidermidis, S.pyogenes and S.aureus, as well as vancomycin-resistant enterococci (in vitro) . Exhibits antimicrobial activity against methicillin-resistant S.aureus, P.mirabilis, and C.albicans in low-salt media, but not in media containing 100 mM NaCl (in vitro) . Forms chiral supramolecular assemblies with quinolone signal (PQS) molecules of P.aeruginosa, which may lead to interference of bacterial quorum signaling and perturbance of bacterial biofilm formation . May form supramolecular fiber-like assemblies on bacterial membranes . Induces cytokine and chemokine production as well as TNF/TNFA and CSF2/GMCSF production in normal human keratinocytes . Exhibits hemolytic activity against red blood cells . .; [Antibacterial peptide FALL-39]: Exhibits antimicrobial activity against E.coli and B.megaterium (in vitro). .; [Antibacterial peptide KR-20]: Acts synergistically with peptides KS-30 and KR-31, killing bacteria such as S.aureus, E.coli and C.albicans at lower concentrations when present together, and maintains activity at increased salt condition . Does not have the ability to stimulate CXCL8/IL8 release from keratinocytes . .; [Antibacterial peptide LL-23]: Poorly active (MIC > 150 uM) against E.coli strain K12 . Is able to induce the pro-inflammatory cytokine TNF/TNFA or the chemokine CCL2/MCP1 . .; [Antibacterial peptide LL-29]: Moderately antibacterial. .; [Antibacterial peptide KS-30]: Moderately antibacterial . Acts synergistically with peptides KR-20 and KR-31, killing bacteria such as S.aureus, E.coli and C.albicans at lower concentrations when present together, and maintain activity at increased salt condition . Does not have the ability to stimulate CXCL8/IL8 release from keratinocytes . .; [Antibacterial peptide RK-31]: Acts synergistically with peptides KS-30 and KR-31, killing bacteria such as S.aureus, E.coli and C.albicans at lower concentrations when present together, and maintain activity at increased salt condition . Does not have the ability to stimulate CXCL8/IL8 release from keratinocytes . .; [Antibacterial peptide FF-33]: Inhibits the growth of E.coli and B.megaterium and exhibits hemolytic activity against human red blood cells. .

Cathelicidin antimicrobial peptide (18 kDa cationic antimicrobial protein) (CAP-18) (hCAP-18) [Cleaved into: Antibacterial peptide FALL-39 (FALL-39 peptide antibiotic); Antibacterial peptide LL-37; Antibacterial peptide KR-20; Antibacterial peptide LL-23; Antibacterial peptide LL-29; Antibacterial peptide KS-30; Antibacterial peptide RK-31; Antibacterial peptide FF-33] CAMP CAP18 FALL39 HSD26

Human

WB

WB 1:300-1:1000

19.301kD;

CAMP CAP18 FALL39 HSD26

p49913

https://www.uniprot.org/uniprotkb/p49913

RKRC41926-Recombinant Cathelicidin Antimicrobial Peptide (CAMP) Gln31~Ser170

Rabbit

Polyclonal

Rabbit IgG

Infection immunity;

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Liquid

0.77mg/ml

0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.