PK57195

货号 规格 价格(¥)
PK57195S 50μl
PK57195M 100μl

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Note:  Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.

注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。

抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。

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经典一抗-FZD1 Antibody

Datasheet

Background

Receptor for Wnt proteins . Activated by WNT7B . Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (By similarity). Contradictory results showing activation by WNT7B have been described for mouse . Functions in the canonical Wnt/beta-catenin signaling pathway . The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes . A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). .

Alternative Name

Frizzled-1 (Fz-1) (mFz1) Fzd1

Reactivity

Mouse

Predicted Reactivity

Application

WB,IHC

Application Image

Recommended Dilution

WB 1:300-1:3000
IHC 1:50-1:200

Mol Weight

71.127kD;

Gene Symbol

Fzd1

Uniprot

o70421

Uniprot link

Immunogen

RKRE57174-Recombinant Frizzled Homolog 1 (FZD1) Gln112~Trp317

Immunogen Range

Source

Rabbit

Clonality

Polyclonal

Isotype

Rabbit IgG

Specificity

Subcellular location

Transmembrane

Research Area

Tumor immunity;

Positive control

Conjugation

Modification

Purification

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Formulation

Liquid

Concentration

500μg/mL

Buffer

PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

产品介绍

Clone

Target

波长

Storage

Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.

注意事项

Companion Products

Important

Comments

RRID

客户评价

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      微信客服

邮箱:market@ab-mart.com

应聘职位:hr@ab-mart.com

订购专线:4006-123-828

销售电话:13916964679(微信同号)

技术支持:15618194176(微信同号)

华南经销商负责(广东,广西,福建,海南):
程经理:手机18616261485(微信同号)
华北经销商负责(北京,天津,河北):
徐经理:手机15618191473(微信同号)
南方经销商负责:

陆经理:手机13122837132(微信同号)
北方及西南经销商负责:

张经理:手机13122150513(微信同号)

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      微信客服

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