MU112166

货号 规格 价格(¥)
MU112166S 50μl
MU112166M 100μl

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Note:  Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.

注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。

抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。

ABMART实验方案下载

   蛋白质免疫共沉淀

   蛋白质印迹

   免疫荧光

   免疫组化

   膜再生

   植物BPP法变性蛋白提取

   组织制备成单细胞悬液

经典一抗-BACE1 antibody

Datasheet

Background

Autosomal dominant Alzheimer's disease is caused by mutations in the gene encoding the β-Amyloid protein precursor (APP). Amyloid β-peptide (Aβ), the major feature of amyloid plaques in Alzheimer's patients, is the product of APP cleavage by β- and γ-secretases. BACE is the transmembrane protease which cleaves Aβ from APP. BACE and the related protein Asp1 are both widely expressed in human tissue, with the highest levels in the pancreas.BACE is localized within Golgi and endosomes.

Alternative Name

Beta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2) BACE1 BACE KIAA1149

Reactivity

Human,Mouse,Rat

Predicted Reactivity

Application

WB,IHC,IF,ICC,IP

Application Image

Recommended Dilution

WB 1:1000
IHC 1:50-500
IF 1:50-500
ICC 1:100-1:400
IP 1-2 μg per 100-500 μg of total protein

Mol Weight

55.7 kDa

Gene Symbol

BACE1 BACE KIAA1149

Uniprot

swissprot: p56817 human

Uniprot link

Immunogen

Immunogen Range

Source

Mouse

Clonality

Monoclonal

Isotype

Mouse IgG1

Specificity

Subcellular location

Transmembrane

Research Area

Neuroscience->Neurology process->Neuroregeneration->Neuroregeneration;Neuroscience->Neurology process->Neurodegenerative disease->Alzheimer's disease->Proteases;Cell Biology->Proteolysis / Ubiquitin->Proteolytic enzymes->Aspartic protease->BACEs

Positive control

SH-SY5Y, human adrenal gland tissue.

Conjugation

Modification

Purification

Protein A affinity purified.

Formulation

Liquid

Concentration

2 mg/mL.

Buffer

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

产品介绍

Clone

Target

波长

Storage

Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.

注意事项

Companion Products

Important

Comments

RRID

客户评价

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      微信客服

邮箱:market@ab-mart.com

应聘职位:hr@ab-mart.com

订购专线:4006-123-828

销售电话:13916964679(微信同号)

技术支持:15618194176(微信同号)

华南经销商负责(广东,广西,福建,海南):
程经理:手机18616261485(微信同号)
华北经销商负责(北京,天津,河北):
徐经理:手机15618191473(微信同号)
南方经销商负责:

陆经理:手机13122837132(微信同号)
北方及西南经销商负责:

张经理:手机13122150513(微信同号)

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      微信客服

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