13916964679
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Cell growth and viability is compromised by oxygen deprivation (hypoxia).Hypoxia-inducible factors, including HIF-1α, HIF-1β (also designated Arnt 1),EPAS-1 (also designated HIF-2α) and HIF-3α, induce glycolysis, erythropoiesis and angiogenesis in order to restore oxygen homeostasis. Hypoxia-inducible factors are members of the Per-Arnt-Sim (PAS) domain transcription factor family. In response to hypoxia, HIF-1α is upregulated and forms a heterodimer with Arnt 1 to form the HIF-1 complex. The HIF-1 complex recognizes and binds to the hypoxia responsive element (HRE) of hypoxia-inducible genes,thereby activating transcription. Hypoxia-inducible expression of some genes,such as Glut-1, p53, p21 or Bcl-2, is HIF-1α dependent, whereas expression of others, such as p27, GADD 153 or HO-1, is HIF-1α independent. EPAS-1 and HIF-3α have also been shown to form heterodimeric complexes with Arnt 1 in response to hypoxia.
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8) HIF1A BHLHE78 MOP1 PASD8
Human,Mouse,Rat
WB,IHC,IF,ICC,IP
WB 1:1000IHC 1:50-500IF 1:100-1:400ICC 1:50-500IP 1-2 μg per 100-500 μg of total protein
132 kDa
HIF1A BHLHE78 MOP1 PASD8
swissprot: q16665 human
Mouse
Monoclonal
Mouse IgG1
Cancer->Cancer Metabolism->Response to hypoxia;Cancer->Invasion/microenvironment->Apoptosis->Death receptors ligands->TRAF;Cancer->Invasion/microenvironment->Apoptosis->Caspases;Cancer->Invasion/microenvironment->Apoptosis->Cytochrome C;Cancer->Invasion/microenvironment->Angiogenesis->Angiogenic growth factors;Cancer->Invasion/microenvironment->Angiogenesis->Angiogenic inhibitory factors;Cancer->Invasion/microenvironment->Angiogenesis->Other;Cancer->Invasion/microenvironment->Hypoxia->Hypoxia-related proteins;Cancer->Tumor biomarkers->Tumor antigens;Metabolism->Pathways and Processes->Metabolism processes->Hypoxia
293T.
Protein A affinity purified.
Liquid
2 mg/mL.
1*TBS (pH7.4), 1%BSA. Preservative: 0.05% Sodium Azide.
Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.
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邮箱：market@ab-mart.com
应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
技术支持：15618194176（微信同号）
华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
华北经销商负责（北京，天津，河北）：
徐经理：手机15618191473（微信同号）
南方经销商负责：
陆经理：手机13122837132（微信同号）
北方及西南经销商负责：
张经理：手机13122150513（微信同号）
微信客服
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