13916964679
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Tuberous sclerosis 1 (TSC1), also known as hamartin, is a protein that in humans is encoded by the TSC1 gene. TSC1 functions as a co-chaperone which inhibits the ATPase activity of the chaperone Hsp90 (heat shock protein-90) and decelerates its chaperone cycle. Tsc1 functions as a facilitator of Hsp90 in chaperoning the kinase and non-kinase clients including Tsc2, therefore preventing their ubiquitination and degradation in the proteasome. TSC1, TSC2 and TBC1D7 is a multi-protein complex also known as the TSC complex. This complex negatively regulates mTORC1 signaling by functioning as a GTPase-activating protein (GAP) for the small GTPase Rheb, an essential activator of mTORC1. The TSC complex has been implicated as a tumor suppressor. Defects in this gene can cause tuberous sclerosis, due to a functional impairment of the TSC complex. Defects in TSC1 may also be a cause of focal cortical dysplasia. TSC1 may be involved in protecting brain neurons in the CA3 region of the hippocampus from the effects of stroke.
Hamartin (Tuberous sclerosis 1 protein) TSC1 KIAA0243 TSC
Human,Mouse
WB,IHC,IF,ICC,FC
WB 1:500IHC 1:200-1:600IF 1:100-1:400ICC 1:100FC 1:500-1:1000
Predicted band size: 130 kDa
TSC1 KIAA0243 TSC
swissprot: q92574 human;swissprot: q9ep53 mouse
Mouse
Monoclonal
Mouse IgG1
Cell Biology->Cell Cycle->Cell Cycle Inhibitors->Other;Cancer->Cell cycle->Cell cycle inhibitors->Other
Hela cell lysate, 293 cell lysate, NIH/3T3 cell lysate, Hela, NIH/3T3, human kidney tissue, human fetal skeletal muscle tissue, PC-3.
Protein G affinity purified.
Liquid
2 mg/mL.
PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.
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程经理：手机18616261485（微信同号）
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徐经理：手机15618191473（微信同号）
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