13916964679
Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意：抗体应用为IHC的，抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的，抗体适合于冰冻切片的组化染色或者荧光染色，以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
Mitogen-activated protein kinase (MAPK) signaling pathways involve two closely related MAP kinases, known as extracellular-signal-related kinase 1 (ERK 1, p44) and 2 (ERK 2, p42). Growth factors, steroid hormones, G protein-coupled receptor ligands and neurotransmitters can initiate MAPK signaling pathways. Activation of ERK 1 and ERK 2 requires phosphorylation by upstream kinases such as MAP kinasekinase (MEK), MEK kinase and Raf-1. ERK 1 and ERK 2 phosphorylation can occur at specific tyrosine and threonine sites mapping within consensus motifs that include the threonine-glutamate-tyrosine motif. ERK activation leads to dimerization with other ERKs and subsequent localization to the nucleus. Active ERK dimers phosphorylate serine and threonine residues on nuclear proteins and influence a host of responses that include proliferation, differentiation, transcription regulation and development. The human ERK 1 gene maps to chromosome 16p12-p11.2 and encodes a 379 amino acid protein that shares 83% sequence identity to ERK 2.
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) MAPK1 ERK2 PRKM1 PRKM2
Human,Mouse,Rat
WB,IF,ICC,IP
WB 1:100-1:1000IF 1:50-1:500ICC 1:100-1:400IP 1-2 μg per 100-500 μg of total protein1:ml of cell lysate
ERK 1: 44 kDa, ERK 2: 42 kDa
MAPK1 ERK2 PRKM1 PRKM2
swissprot: p28482 human
Mouse
Monoclonal
Mouse IgG1
Neuroscience->Neurotransmission->Intracellular Signaling->Kinases;Neuroscience->Neurology process->Neurodegenerative disease->Alzheimer's disease->Tangles Tau;Cell Biology->Cell Cycle->Kinases/Phosphatases->Other;Cancer->Invasion/microenvironment->ECM->Cell adhesion->Other;Cancer->Invasion/microenvironment->Apoptosis->Other;Cancer->Invasion/microenvironment->Apoptosis->Death receptors ligands->IAPs;Cancer->Invasion/microenvironment->Apoptosis->Caspases;Cancer->Signal transduction->Protein phosphorylation->Serine/threonine kinases->AKT;Cancer->Cell Death->Apoptosis->Metabolism;Cancer->Cell Death->Apoptosis->Other;Cancer->Cell cycle->Kinases/phosphatases->Other
A-431, rat cerebrum tissue.
Protein A affinity purified.
Liquid
2 mg/mL.
1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.
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邮箱：market@ab-mart.com
应聘职位：hr@ab-mart.com
订购专线：4006-123-828
销售电话：13916964679（微信同号）
技术支持：15618194176（微信同号）
华南经销商负责（广东，广西，福建，海南）：
程经理：手机18616261485（微信同号）
华北经销商负责（北京，天津，河北）：
徐经理：手机15618191473（微信同号）
南方经销商负责：
陆经理：手机13122837132（微信同号）
北方及西南经销商负责：
张经理：手机13122150513（微信同号）
微信客服
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