Note: Application as IHC, only suitable for histochemical staining or fluorescence staining of paraffin-embedded sections. Application as ICC/IF, suitable for histochemical or fluorescent staining of frozen sections, as well as chemical and fluorescent staining at the cellular level.
注意:抗体应用为IHC的,抗体只适合于石蜡切片的组化染色或者荧光染色。
抗体应用为IF/ICC的,抗体适合于冰冻切片的组化染色或者荧光染色,以及细胞水平的化学染色和荧光染色。
ABMART实验方案下载
The Sarco(endo)plasmic-reticulum (SER) regulatory protein, Phospholamban (PLB), is a small, plasma membrane-associated phospho-protein found in the SER of cardiac, smooth and slow-twitch muscle. Believed to assemble into a pentamer, PLB regulates cardiac contractility and Ca2+ affinity for cardiac SER Ca2+ ATPase (SERCA2a). Non-phosphorylated PLB associates with SERCA2a, and inhibits Ca2+ reuptake into the SER. PLB activation occurs when key Serine/Threonine residues in PLB (Ser 10, Ser 16, Thr 17) are phosphorylated by numerous effectors, which include PKC, PKA, PKG, and CaM kinase. Phosphorylation of PLB causes dissociation from SERCA2a and a subsequent increase in the rate of Ca2+ reuptake into the SER, which accelerates ventricular relaxation.
Cardiac phospholamban (PLB) PLN PLB
Human,Mouse,Rat
WB,IF,ICC,IP
WB 1:100-1:1000IF 1:50-1:500ICC 1:100-1:400IP 1-2 μg per 100-500 μg of total protein1:ml of cell lysate
Oligomer: 25 kDa, Monomer: 6 kDa
PLN PLB
swissprot: p26678 human
Mouse
Monoclonal
Mouse IgG1
Transmembrane
Notch signaling pathway
Mouse heart tissue, human heart tissue.
Protein A affinity purified.
Liquid
0.5 mg/mL.
1*TBS (pH7.4), 1%BSA. Preservative: 0.05% Sodium Azide.
Store at +4℃ after thawing. For long-term storage, please store it at -20℃. Avoid repeated freeze / thaw cycles.
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